umm i draw with it sketching and inking wise and i just use the pencil in the blue layer to sketch and the pen in the other layer to ink don;t know how much help that would be ;-;

I guess it depends on the version. I'm not fully familiar with Manga Studio, but do know there were some major changes between versions 4 and 5, both in interface and features. For example, while MS5 still has panel tools like MS4, it doesn't have a story editor (as in, multiple page support like Adobe InDesign has). So you should be more clear about which version your using to avoid confusion.

lol Love the Groucho quote as your footer but it's misquoted. He wrote in a letter, "Please accept my resignation. I don’t care to belong to any club that will have me as a member." :3

I have Manga Studio Debut 4. I've messed with it a few times. It seemed fairly straightforward, but I only went as far as basic linework within a few frames. http://www.furaffinity.net/view/5370579/

It would be a good start if you told us the version that you are working with and what problems you are having. For a quick ref guide, YouTube is really awesome at giving step-by-step tutorials for art programs. :)

Manga Studio 5. I'm not having any PROBLEMS, I just don't know how all this stuff works, or what I should try out, or what advantages it has over other programs.

I haven't seen another comic-maker program before, so i can't really tell you if it is better or worse. It seems to do basic stuff, but I like the fact that you get speech bubbles of all kinds and the pen tools look great. The downside is that you don't have any airbrush tools to make soft shadows and highlights.

I suppose you can also do comics in Autodesk Sketchbook Pro using the Ruler tool you could use to draw frames of any size or any tilted-rectangular shape, but the caveat to that program is that it saves art in only CMYK and all dark colors have splotchy gray overtones when saved as a PNG or JPG. :P
My last Photoshop was Photoshop CS1, so I don't know any of the features PS can bring these days. Gimp is good, but there doesn't seem to be a ruler tool that can be maneuvered easily in any direction like Autodesk can do.

I've been working with Manga Studio ex 4 for a while, and while not an expert on it, I could answer some or any questions you might have on it.
Otherwise, I'd advise you to check out the Manga Studio Debut and EX 4 Training from Doug Hills on YouTube, which has several short lessons touching on some of the basic and intermediate controls and tools for Manga Studio, which most of them should translate over to your ver. 5, or at least give you a starting point for reference.
Good luck, and feel free to contact me if there's anything I can help with.

Well if you get tired of Manga Studio 5, you might look up Krita. I liked my experience with Krita far better than Gimp and it's a step up from Sai.
You told me about Monoprice tablets so I'm telling you about Krita.

Krita, eh...

I will check it ouuuut. If it's as good as Corel Painter, then I'll be sold.