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Cancer Drug that is 10 Times More Potent
12 years ago
No amount of experimentation can ever prove me right; a single experiment can prove me wrong. -Albert Einstein
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wattsin
So recently the cluster H(CHB_11Cl_11) carborane has been recognized to have some interesting properties. I think fluoroantimonic acid WAS the strongest acid (or was it anhydrous hydrogenfluoride + antimony pentafluoride, I have a hazy memory), but carborane's ability to donate protons allow it to crash the ph scale. Due to its rapid ability to donate protons it is the strongest acid known now. They've started using the cluster's properties to bind with medication to enhance the effect. I feel like this is the star compound of this solstice. Enjoy ;)
ps. This message was lost in the inbox. I stumbled across it and kicked myself for forgetting it. Sorry. >.<
wattsinSo recently the cluster H(CHB_11Cl_11) carborane has been recognized to have some interesting properties. I think fluoroantimonic acid WAS the strongest acid (or was it anhydrous hydrogenfluoride + antimony pentafluoride, I have a hazy memory), but carborane's ability to donate protons allow it to crash the ph scale. Due to its rapid ability to donate protons it is the strongest acid known now. They've started using the cluster's properties to bind with medication to enhance the effect. I feel like this is the star compound of this solstice. Enjoy ;)
ps. This message was lost in the inbox. I stumbled across it and kicked myself for forgetting it. Sorry. >.<
But yeah, definitely looks promising. Carborane is unique in that is very strong and is an amazing proton donor, but at the same time, is not highly corrosive in anyway.
FUCK I love science
Hammet superacid scale:
Fluoroantimonic acid (1990) (H0 Value = −31.3)
Magic acid (1974) (H0 Value = −19.2)
Carborane superacid (1969) (H0 Value = −18.0)
Fluorosulfuric acid (1944) (H0 Value = −15.1)
Triflic acid (1940) (H0 Value = −14.9)
sulfuric isn't quite as acidic according to the superacid scalie (pi).
Yeah, Fluroantimonic Acid was the strongest "Superacid".
Fluorosulfuric acid was the strongest "Strong Acid", but it looks like they reclassified it into Superacid according to the scale you posted.
Well, the very definition of a Superacid is any acid stronger than 100% Sulfuric.
Cool idea to use with medication as well, though there's a long way to go with defeating diseases such as cancer. Designing drugs for cancer is a enough huge problem as it is, what with their uncanny ability to develop resistance by unlocking alternate cellular & metabolic pathways, but hopefully this will unlock another piece of the puzzle. But then again I guess that depends on how specific the targeting of the drug is; I'd have thought an acid with such high proton donating ability would cause widespread havoc if it isn't able to be controlled. Still, wonder how clinical trials will go :3
Intriguing find
Canada beat you to it....