I have Adobe After Effects and need some help with editing since I am not too familiar with the software.
What I am trying to accomplish is to layer a bunch of videos together and create it as one.

The program I recorded is Omegle and Chatroulette and each of those websites are those that have each person use their webcams and chat with each other. What I would like to do is enlarge the video of me, enlarge the video of the other person and place those two separate pieces on top of a background. This effect is similar to that of MrTechnicalDifficult:

Example: https://www.youtube.com/watch?v=jOjoFP1Aqak

Notice how the videos are larger and all of the unnecessary sections of the video are cut out.

This is what I hope to achieve.

If this is also needed I have Adobe After Effects CS6 and have some skills in editing I just need to know which buttons to push and how to get this effect. Thanks.