I've been on HRT for about 2 full weeks since oct 2 when the first dose was administered...I have stared noting changes....Softer fur (skin :P) softer muzzle (face :P) my mate says I have a different scent, I don't small like I did before HRT...and I seem to be more in touch with my feelings....and my therapist does agree....I have been a woman my entire life....I Internalize alot of things.....like a woman unlike men who..well...vocalize it...