It depends on the situation, but I find that a struggle or conflict of this nature can be worthwhile if done correctly.

While not to the same scale as an author to a novel, I have been creating stories and worlds for people to explore by running Dungeons and Dragons games over the last decade. Context is everything. My players understand (at least I hope they do) know that when a touchy subject is part of the story, I have not thrown it in as an afterthought, and if I can't handle the situation with tact, I won't use it in the story playing out before them.

Socio-political struggles such as Transphobia, Abuse, Racial or Gender discrimination, Religious zealotry... All of these need to be handled tactfully if you are using them in your novel. Don't treat them like a Dollar Tree bargain sale.

As a Transwoman I agree with this.

I myself, while cisgendered, am homosexual, and have a transgender friend who has been my closest friend for the past 15 years, both before and after they opened up about their gender identity.

One of the more intriguing (to both of us) D&D stories I have told was a great conflict where the two main regions involved were:

A city-state founded on faith that zealously decries and eradicates those unwilling to follow the true faith they have, and have committed atrocities against any who dare speak out against them.

A magically-prosperous (though behind in tech) aristocracy where slavery is a common practice, magical aptitude takes precedence after race with humans, elves and dwarves being the only ones with any real rights, and slaves are kept in line with magical brands that act as shock collars and minor mind control.

Both are ideologies or cultures that I would damn in the real world, but then again, my players were (and still are) working to ensure both sides lose the conflict.

Edit: I forgot to add that I didn't do either of these on a whim. I wanted to see if my players would be able to see past the "which side should we choose" ideal and find a new path that won't clash with their own ideologies.

my only pointer is i really dont like it when stories blatantly read like revenge fantasies or persecution fantasies. when an author makes the world a trans character inhabits either so heavy handed with its hatred of trans characters or hatred of transphobic characters, it just knocks me out of the story. whether you go with a world where trans is accepted, unaccepted, or a middle ground, as long as it isnt written with overtly blunt malevolent satisfaction within character actions, it should turn out great.

As a writer, myself, I'll point out that conflict is necessary in order to portray a good story dynamic. However, gender politics don't have to be a conflict. There are plenty of others. And while I feel like such a thing could create a good conflict, in many people's eyes it might seem to be pandering to those who struggle through such things. At the same time, doing the opposite could have the exact same issue. It's a very difficult subject to write, and you need to be very careful how you portray things. So while I've not really given advice on which way you should write it, i will strongly advice caution. It's a very touchy subject with a lot of people these days, and I'd hate for you to suffer from undeserved backlash.

I feel like any topic can be written about and received well if handled tactfully and tastefully. Many a novel throughout history has had a myriad of unpleasant topics, some even reshape the boundaries of what is and isn't appropriate for literature. Obviously, your target audience is the main factor - you wouldn't write a book like Game of Thrones and have young teens be the target audience. XD
I feel that if a character is to become "real", real situations must happen; not all of the real things need to happen, mind you - but daily struggles and triumphs must happen. Consider looking into psychological, social, and emotional aspects through other reading; personal experience is ALSO very helpful in the creative process. As far as a story with a trans character goes? Go for it. Having a character to relate to can not only make the character come alive for the reader, but can also help the reader feel as though they are there.