Note: All done in Garry's Mod. Comments are appreciated.

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This is largely in part to flitchard providing some fuel for the duo here, but they are indeed siblings if the title didn't state it enough. The catch though - and something common among the macro/micro scene - is that Wesley, the shiny weavile, is the older brother, while Selene, the sneasel, is the younger sister of the two.

Wesley was born a couple inches shorter than the average, but not too much to be actively viewed as a runt. The effects of the quirk he had really kicked in once he evolved, being unable to grow past two inches in size. Selene got the opposite of such, being almost double the average size of a sneasel at close to five and a half feet, and as such towers over her older brother. She takes care of him though since she's easily able to hear him since she also has more sensitive hearing than others, and coupled with a naturally sharp eyesight, makes it so she's the most adept at handling her tiny brother. While Selene is fairly dominant towards her brother if due to his size, she does such with good intentions since the various measures of having him treat her is to double as a way of getting some form of training in since it would be impossible for Wesley to train himself normally.

One thing though is that Wesley is prone to 'shrinking spells', which he goes even smaller by varying amounts for a period of time before growing back to his previous size. There doesn't seem to be a limit on how small he can get though, since it's entirely possible for him to get so small that even his own sister won't be able to see or even hear him. Despite such, Selene does care if her brother goes through a shrinking spell, more so if she wasn't around to see it happen since she can 'sense' when he starts shrinking but can't pinpoint where he's at once it starts.

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Map(s) used: gm_gtav_mp_apa_06, gm_fork, gm_supersizedroom.
Tool(s) used: Ragdoll Mover, Ragdoll Resizer (OLD), Model Manipulator, Advanced Bone Tool, Easy Bodygroup Tool.
All visual effects are achieved with the use of the Super DoF(Depth of Field) and usage of Life Mod, which allows various color alterations, hues, and bloom effects to make for some truly spectacular shots.

Selene, Wesley are both co-owned between me and  flitchard.
Sneasel, Weavile © Nintendo, GAMEFREAK, Creatures Inc..
Garry's Mod © Facepunch Studios/Garry Newman, Valve.