Duke Nukem's from 2K's Duke Nukem, Johhny Cage's from Warner Bros.'s Mortal Kombat, Lady Deadpool's from Marvel Comics and this screenshot's taken from Valve's Garry's Mod.

Johnny's low-blowing technique has been backfired, thanks to the fact that Duke got himself the Ballz of Steel, causing his hand to crack in the strange way. Even Lady Deadpool is surprised to witness this crazy situation.