The Remington 870 Express Combo, featuring both a 20" slug barrel and a 28" ventilated rib barrel, was introduced in 1988, according to American Rifleman. The 870 Express model itself, a more budget-friendly version of the Wingmaster, debuted in 1987. The Express model distinguished itself by using hardwood instead of walnut for the stock and forend, and by foregoing some of the polishing done on the Wingmaster.

In Resident Evil 4 (2005), it is available for purchase from the Merchant for 20,000₧. However, a free Model 870 Express Combo is available on the second floor of the house in the village. If the game is started on Easy mode, Leon starts with one in his inventory, but there is no shotgun to take in the village.

Remington Model 870 Express Combo is powerful at close range, but damage and stopping power decreases over range. It takes up 16 spaces (8x2) of inventory and uses 12 Gauge Shotgun Shells. Model 870 Express Combo also appears as part of the "Rapid Fire" weapon set in the Shooting Range minigame.

Model 870 Express Combo costs 277,000₧ to buy and fully upgrade, or just 257,000₧ to fully upgrade if the player takes the Model 870 Express Combo in the village or keeps the one they start with in easy mode. Its exclusive allows it to have a firepower of 8.0 at long range. This interesting mechanic means that one pellet can cause substantial damage normally limited to the shotgun's close range shooting.

Examining on the Model 870 Express Combo
"A 12-gauge pump-action shotgun. Don't leave home without it."

Fully upgraded examining on the Model 870 Express Combo
"Now possess the same destructive power from all distances. Sounds like a winner to me!"

Exclusive Upgrades for the Model 870 Express Combo
"Significantly increases the destructive power of the weapon for long distance targets!"