After birth, Albert went to Spencer's boarding school. Trying to come up with a cure for smallpox, the old man conducted experiments on children, which caused many to die in agony. Only Albert survived, in return giving up the healthy appearance of his own face.

While his deformed appearance scared people, Spencer saw something more in him. Gave him some significance of his own, confining him with physical chains. But Wesker escaped, unable to bear the disgusting life.
Once in Paris, he hid in the local opera house for many years. It was from Spencer that he got his fascination with disease, and the goal of curing himself. But as time went on, his hope for a cure slowly faded. He even became interested in music in order to spend his infinitely free and terribly lonely time on something.
He never occured that he had lived his whole life without care and compassion, all alone. He was thrown into a cruel world from birth. And it seemed that there was no need for the company... until he met someone.
Christopher Redfield, the new usher, touched something long dead in the soul of the man living in the basements of the opera house. And aroused so much interest that Wesker wanted to possess him. To take Chris for himself. So that the taste of life that he felt would never leave him.