Eep! I know I wouldn't want to be in this situation. So close to losing humanity. Im not sure if you meant it as the actual cause, but i've always been a fan of that.. once you fall to all fours in a TF it sort of brings most of the transformation to a close or wraps it up.

As for losing one's humanity once one hits the floor per say, I think it all depends on the story. In my book, the character gets full wolfed pretty early on, and the remainder of the story revolves around this character trying to preserve his indenity, despite everything going on around him. Also, remember what Fennex says, he eludes to one thing, but something else happens... Of course he could be eluding to the fact that he is eluding, and for all we know poor Jimbo now has the full mentality of a happy dog... Poor Ashley...

Well as the story has been going, they've only been losing physical, and not mental things. The change in voice is probably just them losing vocal ability, but not mental state. Like how the protagonist had the colours shift previously.

For whatever reason Jimbo reminds me of my chubby labby... Wiggles... :) Now I'm excited to see page 19... :P Poor Jimbo... it seems nothing good comes his way. I guess Ashley better think fast...while she can think. :D

Well in essence if a person completely loses their humanity you essencially are killing then off by erasing their existence. It's kind of like The Fly where Seth loses a bit of his humanity each time he phases. It's dying... All of these twists and turns makes me wonder how this series is going to end.

Since we are discussing a TF and the loss of humanity, I wanted to bring up another TF artist (Japanese) who has delved into similar territory. http://www.furaffinity.net/view/1891054/
So that you understand the backstory, just in case you haven't followed Nojo's work. Mary, the character, Michael's sister, got possessed by an evil witch when she put on a magic ring. This particular witch is akin to Circe, and likes to play cruel jokes. Mary, being a little girl, is only capable of battling this monster every now and then. Earlier in the story, the witch actually helped Mary get rid of a bully, but the witch is about to go over the deep end, as she has targeted Mary's beloved brother, and the only one in her family that was ever nice to her. The story, much like Fennex' starts out rather playful, but near the end, it gets very dark. The last frame is one of the saddest I've ever seen thus far.

Nojo's particular sequence actually inspired me, long ago that is, on how to work a particular sequence near the end of my fantasy epic, "Tales of Ulrica: The Wolf Prince". Much like this comic, the story lends itself to being lighthearted as the protagonist while not always an optimist, is rather funny, but that balances the fact that the story itself is incredibly dark, especially during the last third of the book...

Oh yes, Nojo is definitely one of the best TF artists of the moment. The themes he deals with and his unique style of visual storytelling are absolutely haunting.

I really like how he can make something that is incredibly dark, playful. That was the largest struggle I had with "Tales" as the story gets incredibly dark, and yet if I didn't keep it funny at times, people would really get depressed.

That is also why I like your work. You keep it funny, but ultimately your story is pretty darn scary. :)