Awesome with Lasers uses a two-stage process I've been trying out more recently. This is the (first) half done in Flash, which is all flats and ink and a transparent background not seen here, like an acetate cel. Working in brushlike vectors is pretty darn great, because each colour block is a distinct object with borders, so even though it's rendered antialiased throughout the whole process, you can do seamless filling, refilling, and paint-behind/inside. For example, Jena's tail colouration is perfectly bounded by the plain region I originally blocked it out as.

Next.