In all honesty, I would have to say Jessica Rabbit. X3

cattleya from queen' blade

Sara titan : http://www.furaffinity.net/view/12785167/

Not too big on the human girls in video games, especially the fanservice ones (I prefer furries for my fanservice).

If I had to pick, I'd say it's a tie between The Boss from MGS3 and Chell from Portal

Hehe, I guess Tifa Lockheart is the first that comes to my mind.

Hmmm, I'd say catnis from the hunger games or Jessica nigri that hot cosplayer

Major Motoko Kusanagi of GITS

I would date Diablo from Blizzard's Diablo Series... or Evangelion (aka EVA-01) from Neon Genesis Evangelion. Moreover, I would date Wolverine from the X-Men comics, among others.

Spock. 8I

Saber from Fate/Zero. =3

o_o
On just a date? Aw geez that's a toughie... Nope. Can't think of any.

Leo from Tekken. (For me, it is a she)

If a somewhat human character, I would most likely go out with Kneesocks from the anime Panty & Stocking With Gartherbelt, the single horned red lady with blue hair..
She's so damn cute when she blush, she's a bit kinky and got a hot body for a demon.

My fave episode with her involved in it: http://www.youtube.com/watch?v=YKz5mEaonMU
7:33 - 7:48 for my fave scene in the vid.

But I suppose most people would like her most in this vid: http://www.youtube.com/watch?v=DxRR6J1ZYAw