Cats hate to be shut in.

but when he's in the house he's fine. the room he is in is bigger than my own bedroom, hes got toys, food, water, litterbox, a soft bed, everything he could ever want in there.

He does not feel trapped in the house, but when you shut him in a room he does. It does not matter how big the room is or whats in there.
He is going to be very upset because he feels trapped and the door is closed.

The only way to make him feel better and not freak out is to leave the door open.

There's no real issue with what you're doing, especially since it's for his safety, but you have to realize you're basically trapping him in a big wooden box, he can hear things outside but he can't see or do anything about it. It doesn't matter how big the room is if he's feeling trapped, lonely, and understimulated.

My first recommendation would be to put some shelving or boxes up that he can climb, and make sure that he can get a good view out the window. Cats like to be up high, it makes them feel safer. Similarly, giving him something that he can hide inside of can help as well, think cat tree or even just a cardboard box. Don't ever corner them in a box, though, because a real cat hiding spot has to be someplace the cat feels safe in. If they don't feel safe there, they won't use it.

Make sure there's toys that he can play with, the kinds designed without human interaction in mind that will engage his prey instinct while you're not there to stimulate him. Good toys that aren't just toy mice (though that would be helpful too, the crinkly kind with catnip) would be one of those track ball toys, or possibly a puzzle feeder? Look them up, they're engaging toys that dispense treats.

Is he able to relieve himself if he has to use the bathroom? If there is a litter box present, the addition of the aforementioned shelving or boxes that he can climb out of can let him escape feeling like he's stuck in his own toilet. Make sure whatever food/water is left for him is similarly elevated and accessible, for his comfort.

I hope any of these suggestions help, friend. Best of luck with your buddy!

He has boxes, food, water, litterbox, toys of all sorts (catnip does nothing for him weve tried) and a couple puzzle feeders i fill before i go to bed. He's smart though, so he's very good at cracking those puzzle feeders fairly easily. I guess ill just keep doin what i can, and ask for some help at work too.

I figured he had the stuff he "needs", but I'm not noticing that you mentioned shelving - which was the main point of my comment. You don't even have to screw anything into the walls, just align furniture in such a way that he can get up to higher places in the room and make sure he can perch by the window.

Being able to view out the window and get up high will tremendously help his ability to self-stimulate.

If catnip toys don't work you should look up Valerian root or silver vine based toys and sprays.

never heard of valerian root, thanks. I'll try to get some stuff he can climb on. theres some chairs and stuff in there he can get on if he wants to, but ive never seen him climb anything, ever.

Along with all of the other suggestions above, about an hour before bedtime, wear that cat out playing with him. A tired cat is much less likely to make noises at night.

You should leave the door open at night he doesn't like being shut in the room.

You can either put breakables away and leave the room open, or create more interaction IN the room. Shelving, cat walks, another tree, tunnels. Play with him for 15-20 minutes before you go to bed, get a nice teaser like a Da bird and engage him. Clicker train him, work him and his mind out. A tired cat is a happy cat and cats are most active in the evenings and dawn if not tired and taught that night time is bed time.

I've noticed that no one has asked you if he's neutered. If he's not, is there a possibility that there are female cats outside, in heat? That would explain his constant need to be outside, even when you don't want him to be.

Sorry I don't have any good advice but I wanted to wish you luck with the cat! :(