When it comes to having so many characters, one will have to consider how and what universe do they interact in. I put some thought into it and thought it could work. It would help keep laws consistent to each universe and wouldn't allow characters to be sticking out like a sore thumb. So, I came up with an acronym involving three separate universe for my characters to dwell in.

S.T.U.

S Universe
Stands for Special. This universe is populated mostly with superhero and empowered beings who live among the mundane. Characters like Star Guardd, Lovett Boltt and Dough-Mutt live in this universe.

T Universe
Stands for Toony. This universe has characters that are cartoonish, subjected to cartoonish antics, but mostly mundane interacting with each other. Some instances of the other two universe could happen here. Characters like Orson Major, Bulk, Lucius, Fridolf and Winkle live here. Characters that appear in the other two universes are reduced to characters to a medium here as if they were fictional. E.g. Star Guardd would be a comic book character or Konana's show would be a cartoon series. I'm currently focusing on this universe here. Taking a break from superhero stuff and taking root in mostly mundane.

U Universe
Stands for Unusual . This universe takes a page out of mostly fantasy, or fantastical happenings. May have some sci-fi elements here as well. Characters like Konana, Brutus, Moonsy, Octagon Orson can appear here.

It took some thought for me to come up with this. I hope I can just stick with it!