Yopo, also known as Cohoba, Ebene, Jopo, Mopo, Nopo, Parica, or Calcium Tree, is a species of tree (Anadenanthera peregrina) native to the Caribbean and South America, whose seeds or "beans" are used as an entheogen by peoples indigenous to the region. Yopo beans contain a number of psychoactive compounds, the most important of which is Bufotenin, a psychedelic structurally similar to DMT. The beans are typically removed from their pods and toasted until they burst in a manner similar to popcorn, before being ground into a powder and mixed with lime. This mixture is then moistened to a doughy consistency and kneaded into a ball, before being allowed to dry. The finished product is administered by being blown through a bamboo tube directly into the nostrils of the user, and its effects typically last for between two and three hours.

Among those groups who regularly make use of Yopo in a medicinal or ritual context are the Yanamamo people of southern Venezuela and northwestern Brazil, who believe that it allows them to percieve and interact with animal spirits known as "xapiripë." During a Yopo ritual, participants seek to take these spirits into their bodies, thus granting themselves spiritual power, ridding themselves of disease, and perhaps even transforming themselves into fearsome and respected animals such as jaguars. Belief in the transformative power of Yopo is bolstered by the strange behavior of those under its influence, who are sometimes known to experience unusual fits and contortions.