I usually try a lot of new programs to paint or animate, but the winner is always Paint Tool SAI.

But here is the list!
Draw/Paint:
Paint Tool SAI
Photoshop
Fireworks (pixel stuff)

Animation:
Adobe Flash
Toon Boom Studio (trying to do new stuff)
SAI (Yeah, is not for animation but I like to draw the frames layers and make a animation of it)
Fireworks (gif stuff)
Photoshop (trying to understand that bug program t_t)
Easytoon (old pixel black n white style)

And you?! Comment!